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Formalin-containing fixatives

Formalin-containing fixatives
Formalin or formaldehyde is the gold standard in histological and anatomical fixation. Most common fixatives are based on formaldehyde in different concentrations. Usually a 4% formaldehyde solution is used, which is often referred to as 10% formaldehyde, but effectively contains 4% of the chemical formaldehyde. Depending on the application or type of tissue, it is advisable to use higher concentrations. Important for the result is to consider the penetration and reaction speed. This is approx. 5 mm in 12 hours for a 4% formaldehyde solution and a reaction time of 24-48 hours for the methylation of the amino groups. Short residence times inevitably lead to weaker fixation results because the fixation reaction is terminated prematurely. MORPHISTO formalin-containing fixatives are optimized for penetration and reaction speed, have defined pH values and formaldehyde concentrations and deliver outstanding results.

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