Picric acid orange G solution is a histological staining solution used in tissue staining and cell preparation. This solution consists of a combination of saturated aqueous picric acid and Orange G dye.

Picric acid is a strong oxidizing agent and a fixative that effectively fixes and preserves cell and tissue structures while maintaining morphology and intracellular components. The addition of Orange G, an azo dye, enables the staining of various tissue components, especially cell nuclei and membranes, which allows differentiated visualization of various tissue components.

Picricric Acid Orange G Solution is widely used in histology and cytology to enhance contrast between different tissue types and cell structures. This staining solution is particularly useful for the study of tissue specimens that require good preservation of cytoplasmic detail and visualization of extracellular matrix structures, such as collagen fibers and reticulin fibers.

The use of this staining solution allows researchers and pathologists to better visualize and analyze the morphological characteristics and composition of tissues and cells, which is critical for proper diagnosis and a better understanding of the biological processes involved.