Acid-based decalcification of bone tissue can lead to swelling of collagen fibers, which can compromise tissue structure and lead to artifacts in subsequent histologic examination. The decalcifier post-treatment solution is specifically designed to reduce this swelling process while removing acid residues that could lead to precipitation in the tissue.

Using this post-treatment solution protects tissue structure and preserves cell morphology, which is important for accurate histologic analysis. The post-treatment solution works by restoring the swelling collagenous fibers and neutralizing the acidic environment created during the decalcification process.

After applying the decalcifier post-treatment solution, the bone tissue is thoroughly rinsed to remove any remaining solution residue. The tissue can then be processed in further histological procedures, such as kerosene embedding, thin section cutting and staining.