DAVIDSON solution, modified (L), is a versatile preparation that has become widely used in the practice of histology, especially in scientific laboratories. It is used as a highly efficient fixative in specimen preparation: it reduces tissue shrinkage and preserves fine morphological details. Complementarily, it serves as a diagnostic agent in vitro.

The composition of the modified DAVIDSON solution includes four essential ingredients: Water, formaldehyde, ethanol and acetic acid. Formaldehyde (CAS No.: 50-00-0) acts as a primary fixative and forms a stabilizing structure by forming methylene bridges between proteins. Ethanol (CAS No.: 64-17-5) has a supporting effect in the fixation process as well as in the dehydration of the tissue. Acetic acid (CAS No.: 64-19-7) modulates the aggressive fixation properties of formaldehyde and contributes to the maintenance of non-covalent bonds.

The use of the modified DAVIDSON solution can contribute to the improved morphology of tissues, especially soft tissues, and allows higher quality preparation of samples for subsequent analyses. In conclusion, modified DAVIDSON solution is an effective tool for preservation and morphology conservation in histology.