Ponceau fuchsin solution is a staining solution commonly used in histological and cytological research. It consists of a combination of ponceau and fuchsin dyes, usually dissolved in an alcoholic solvent. Ponceau-fuchsin solution is used to selectively stain various cell and tissue structures.

Ponceau dyes are acid dyes used in histology and cytology because of their ability to bind proteins and acidic tissue components. Fuchsin is a basic dye that binds to basic components in cells and tissues, such as nucleic acids and other basic tissue components.

The combination of these dyes in the Ponceau Fuchsin solution allows for differential staining of cell structures and tissues to more easily identify and examine the various components. This staining solution can be used in various histological and cytological protocols and is particularly suitable for staining connective tissue, muscle tissue, nervous tissue and other tissue types.