Sodium dihydrogen phosphate 0.066 mol/l is used to prepare buffer solutions and is one of the two components for Sörensen buffer solutions. The main component of this solution is sodium dihydrogen phosphate monohydrate.

Sörensen buffers are significant buffer systems consisting of a combination of weak acids and their corresponding bases. This solution, containing sodium dihydrogen phosphate, is often mixed with another solution containing, for example, potassium dihydrogen phosphate to produce a Sörensen buffer. The different concentrations of the two components determine the resulting pH of the buffer solution.

Sörensen buffer solutions help maintain chemical reactions by minimizing fluctuations in pH. This is realized through the buffering action of sodium dihydrogen phosphate, which can release or absorb protons to maintain a constant pH.

Possible application results of this buffer system include stabilization of biochemical and enzymatic reactions, cell culture media, and analytical procedures such as titrations and electrophoresis.