Glutaraldehyde fixing solution (pH 7.2) is an aqueous solution, which due to its special composition is suitable for use in the fixation of biological samples, where fixation in the range of physiological pH is important. The contains sodium chloride, di-sodium hydrogen phosphate dihydrate, potassium dihydrogen phosphate and glutaraldehyde.

The main areas of application of this solution are in the field of fixation of cell and tissue samples. It is particularly used in histological examinations as well as in high-resolution microscopic techniques such as electron microscopy. The fixation properties are crucial for the preservation of the sample structure as well as its morphological characterization.

The chemical mechanism behind the effectiveness of glutaraldehyde fixation solution is the formation of covalent cross-links between proteins within cells and tissues due to the contained glutaraldehyde. This stabilizes the structures and protects them during further preparation. The buffer substances - di-sodium hydrogen phosphate dihydrate and potassium dihydrogen phosphate - keep the pH in an optimally effective range (7.2), which is significant for effective fixation performance, sodium chloride is added in isotonic amount so that there is no osmotic gradient between tissue (cells) and fixative.

The special suitability of glutaraldehyde fixative solution with a pH of 7.2 is its ability to provide efficient and reliable fixation of cell and tissue samples. The chemical properties of glutaraldehyde and the buffer substances enable the preservation of the structure as well as morphology of the samples during further analytical procedures for precise examination.