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Glutaraldehyde fixing solution according to KARNOVSKY

Karnovsky's glutaraldehyde fixing solution is a commonly used histological fixing solution used to preserve cell and tissue structures in the preparation of tissue sections and cell preparations. This fixing solution was originally developed by Karnovsky in 1965 and consists of a mixture of glutaraldehyde and paraformaldehyde in a phosphate-buffered medium.

Karnovsky fixing solution provides excellent fixation and preservation of cell and tissue structures, especially fine intracellular structures such as cell membranes and organelles. This makes it a preferred choice for electron microscopy, where high resolution and precise visualization of fine structures are required.

In addition to electron microscopy, Karnovsky's glutaraldehyde fixing solution can also be used in light microscopy when particularly good preservation of cell structures is desired. Fixation with Karnovsky's solution provides excellent stability and allows observation and analysis of cell structures in a variety of experimental and diagnostic applications.

Article no.: 10204

Fixation for electron microscopy

  •   Container size and order number Net price Amount
    Glutaraldehyde fixing solution according to KARNOVSKY - 100 ml
    Order number: 10204.00100
    43,44 €
    Glutaraldehyde fixing solution according to KARNOVSKY - 250 ml
    Order number: 10204.00250
    59,10 €
    Glutaraldehyde fixing solution according to KARNOVSKY - 500 ml
    Order number: 10204.00500
    88,57 €
    Glutaraldehyde fixing solution according to KARNOVSKY - 1.000 ml
    Order number: 10204.01000
    170,50 €

Important Information

UN-Nummer: 2922

Warning labels:

Lagerung: 4 … 8 °C

Haltbarkeit: 14 Tage

safety data sheet


product information

Relevant Incredients:
• Paraformaldehyde
• Glutaraldehyde 25%
• Hydrochloric Acid 37%
• Cacodylic acid sodium salt trihydrate

Technical informations

specifications

Instructions / Protocol / Recommendations

Verwendung:

The Karnovsky Fixing Solution is used in in vitro diagnostics for the preservation and stabilization of biological samples. Due to its composition of paraformaldehyde, glutardialdehyde, hydrochloric acid and cacodylic acid sodium salt, it enables effective cross-linking of proteins and cell structures, optimally preserving the samples for further investigations, such as electron microscopy, thus ensuring precise results.

Prinzip:

Karnovsky fixing solution is a fixing solution used in in vitro diagnostics to preserve the structure of cells and tissues by chemical cross-linking of proteins. It consists of paraformaldehyde, glutaraldehyde, cacodylic acid sodium salt, hydrochloric acid and water. Paraformaldehyde and glutaraldehyde are aldehydes that cross-link proteins, thereby stabilizing cell structure. Cacodylic acid sodium salt acts as a buffer to maintain optimal pH. Hydrochloric acid is added to generate an acidic pH, which improves the reactivity of the glutaraldehyde. The combination of these chemicals enables efficient fixation of cells and tissues for microscopic analysis and other in vitro diagnostic applications.

Verfahren:

Karnovsky fixing solution is a fixing solution used in in vitro diagnostics to preserve the structure of cells and tissues by chemical cross-linking of proteins. It consists of paraformaldehyde, glutaraldehyde, cacodylic acid sodium salt, hydrochloric acid and water. Paraformaldehyde and glutaraldehyde are aldehydes that cross-link proteins, thereby stabilizing cell structure. Cacodylic acid sodium salt acts as a buffer to maintain optimal pH. Hydrochloric acid is added to generate an acidic pH, which improves the reactivity of the glutaraldehyde. The combination of these chemicals enables efficient fixation of cells and tissues for microscopic analysis and other in vitro diagnostic applications.

Hazard and safety instructions

Signal Word 1: Gefahr
Signal Word 2: acid_red, skull, silhouete,
Warning labels: